Side-by-Side Comparison

Factor	Ozempic	Trulicity
Active Ingredient	Semaglutide	Dulaglutide
Manufacturer	Novo Nordisk	Eli Lilly
FDA Approval Year	2017	2014
FDA Indication	T2D primary; weight secondarily	T2D primary; CVD secondary
Formulation	Weekly subcutaneous injection	Weekly subcutaneous injection
Dosing Frequency	Weekly	Weekly
Starting Dose	0.25 mg	0.75 mg
Maximum Dose	2.4 mg	4.5 mg
Weight Loss (key trial)	~5–10% (diabetes label); up to 14.9% in STEP-1 at 2.4 mg (Wegovy indication)	~4.5% body weight at 4.5 mg (AWARD-11, 36 weeks)
Key Trial	SUSTAIN-6	AWARD-11
Cash Price (est. Q1 2026)	$900–$1,000/month	$700–$800/month
CVD Outcome Benefit	Yes	Yes

Cost estimates based on Q1 2026 data. Weight loss from named pivotal trials. Individual results vary. Verify current pricing with your pharmacy.

Which Is Right for You?

The "better" medication depends entirely on your individual medical history, insurance coverage, treatment goals, and tolerability. Here are key decision scenarios:

★ Primary goal is maximum weight loss

Based on clinical trial data, Trulicity has demonstrated higher percentage weight loss in pivotal trials. Discuss whether the magnitude of difference is clinically meaningful for your situation with your prescriber.

★ You have type 2 diabetes as primary concern

Ozempic and Trulicity are FDA-approved for T2D management. Your prescriber will consider HbA1c targets, cardiovascular risk, renal function, and cost when choosing between them.

★ Cost is a primary factor

Cash prices differ significantly between medications. Ozempic costs approximately $900–$1,000/month/month without insurance; Trulicity costs approximately $700–$800/month/month. Both manufacturers offer savings programs for commercially insured patients. Use our Cost Estimator → to compare your specific situation.

Side Effect Comparison

Ozempic Common Side Effects

•Nausea
•Vomiting
•Diarrhea
•Constipation
•Fatigue
•Injection Site Reaction
•Headache

Trulicity Common Side Effects

•Nausea
•Diarrhea
•Abdominal Pain
•Vomiting
•Fatigue
•Injection Site Reaction
•Headache

Both medications share GI-related side effects as the most common adverse events. The profile is very similar because both belong to the GLP-1 receptor agonist class (or include GLP-1 agonism). Differences in tolerability are individual and cannot be predicted in advance.

Cost Comparison

Scenario	Ozempic	Trulicity
Cash pay / no insurance	$900–$1,000/month/mo	$700–$800/month/mo
Commercial insurance	$25–$75/month with commercial insurance and Novo Nordisk savings card	$25–$50/month with commercial insurance and Eli Lilly savings card
Mfr. savings program	Novo Nordisk Patient Assistance Program (PAP) and Ozempic Savings Card (eligible commercially insured patients may pay as little as $25/month)	Eli Lilly Trulicity Savings Card

Estimated based on Q1 2026 data. Always verify with your pharmacy or plan.

💰 Estimate your personalized monthly cost →

Switching Guidance

If switching between Ozempic and Trulicity, consult your prescriber about the transition protocol. Key considerations include:

Whether to allow a washout period or transition directly
Starting dose for the new medication (may not match your current dose)
Insurance prior authorization requirements for the new medication
Monitoring frequency during transition

See our drug conversion calculator → for dose equivalency guidance.

Ozempic vs Trulicity: Which Is Better for Weight Loss in 2026?